Journal article
Cortico-cognition coupling in treatment resistant schizophrenia
WT Syeda, CMJ Wannan, AH Merritt, JM Raghava, M Jayaram, D Velakoulis, TD Kristensen, RF Soldatos, S Tonissen, N Thomas, KS Ambrosen, ME Sørensen, B Fagerlund, E Rostrup, BY Glenthøj, E Skafidas, CA Bousman, LA Johnston, I Everall, BH Ebdrup Show all
Neuroimage Clinical | ELSEVIER SCI LTD | Published : 2022
Abstract
Background: Brain structural alterations and cognitive dysfunction are independent predictors for poor clinical outcome in schizophrenia, and the associations between these domains remains unclear. We employed a novel, multiblock partial least squares correlation (MB-PLS-C) technique and investigated multivariate cortico-cognitive patterns in patients with treatment-resistant schizophrenia (TRS) and matched healthy controls (HC). Method: Forty-one TRS patients (age 38.5 ± 9.1, 30 males (M)), and 45 HC (age 40.2 ± 10.6, 29 M) underwent 3T structural MRI. Volumes of 68 brain regions and seven variables from CANTAB covering memory and executive domains were included. Univariate group difference..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors thank Prof. Andrew Zalesky (Melbourne Neuropsychi-atry Centre) for his insightful suggestions about the MB-PLS-C tech-nique. CP received funding from National Health and Medical Research Council, Australia (1196508, 1150083) . BE received funding from The Lundbeck Foundation, Denmark (R316-2019-191) .